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Biometra TAdvanced -; the high-performance thermal cycler for DNA amplification by PCR High-Speed Thermal Block The Biometra TAdvanced Thermal Cycler is available with different block formats. The Quick Block Exchange technology allows for an easy exchange of block modules. All blocks are made of aluminum and offer high ramp rates for fast protocol running times. Additionally, to achieve ultimate performance a 96 well block made of silver is available. Due to its excellent heat conductivity, silver equilibrates extremely quickly, thus providing maximum speed and temperature uniformity. To protect the valuable silver blocks against corrosion the block surfaces are gold plated. Rubber sealing at the lid creates an encapsulated space when the lid is closed. The closed room serves to improve the temperature uniformity of the sample block and avoids formation of condensed water at the final PCR cooling step. High-Performance Smart Lid (HPSL) The heated lid of the Biometra TAdvanced is equipped with HPSL technology. An integrated slip clutch always maintains constant contact pressure, regardless of the shape and height of the plasticware. This optimizes the contact between the sample block well and the walls of the plasticware, resulting in reproducible conditions. As soon as the heated lid is closed, a rubber seal on the lid encapsulates the space surrounding the sample block. This closed space increases the sample block temperature uniformity and prevents condensation formation during the final PCR cooling step. The Biometra TAdvanced comes with a one-touch opening mechanism -; just press the locking mechanism, and the heated lid swings open. A spring mechanism holds the lid in the open position, preventing it from dropping down. The locking mecha